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Research articles
2011
 Takács, B., O'Neall-Hennessey, E., Hetényi, C., Kardos, J., Szent-Györgyi, A. G., Kovács, M. (2010): Myosin cleft closure determines the energetics of the actomyosin interaction. FASEB J. 25: 111-121.
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2010
Radnai, L., Rapali, P., Hodi, Z., Suveges, D., Molnar, T., Kiss, B., Becsi, B., Erdodi, F., Buday, L., Kardos, J., Kovacs, M., Nyitray L. (2010): Affinity, avidity and kinetics of target sequence binding to LC8 dynein light chain isoforms. J. Biol. Chem. 285: 38649-38657.
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Málnási-Csizmadia, A., Kovács, M. (2010): Emerging complex pathways of the actomyosin powerstroke. Trends Biochem Sci. 35: 684-690.
PubMed Abstract
Nagy, N. T., Sakamoto, T., Takács, B., Gyimesi, M., Hazai, E., Bikádi, Z., Sellers, J. R., Kovács, M. (2010): Functional adaptation of the switch-2 nucleotide sensor enables rapid processive translocation by myosin-5. FASEB J. 24: 4480-4490.
PubMed Abstract
Takács, B., Billington, N., Gyimesi, M., Kintses, B., Málnási-Csizmadia, A., Knight, P. J., Kovács, M. (2010): Myosin complexed with ADP and blebbistatin reversibly adopts a conformation resembling the start point of the working stroke. Proc Natl Acad Sci U S A. 107: 6799-804.
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Gyimesi, M., Sarlós, K., Kovács, M. (2010): Processive translocation mechanism of the human Bloom's syndrome helicase along single-stranded DNA. Nucleic Acids Research 38: 4404-14.
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Gyimesi, M., Sarlós, K., Derényi, I., Kovács, M. (2010): Streamlined determination of processive run length and mechanochemical coupling of nucleic acid motor activities. Nucleic Acids Research 38: e102.
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2009
Forgacs, E., Sakamoto, T., Cartwright, S., Belknap, B., Kovács, M., Tóth, J., Webb, M. R., Sellers, J. R., White, H. D. (2009): Switch 1 Mutation S217A Converts Myosin V into a Low Duty Ratio Motor. J. Biol. Chem. 284: 2138-49.
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2008
Takagi, Y., Yang, Y., Fujiwara, I., Jacobs, D., Cheney, R. E., Sellers, J. R., Kovács, M. (2008): Human myosin Vc is a low duty ratio, non-processive molecular motor. J. Biol. Chem. 283: 8527-37
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2007
Iwamoto, H., Oiwa, K., Kovács, M., Sellers, J. R., Suzuki, T., Wakayama, J., Tamura, T., Yagi, N., Fujisawa, T. (2007):
Diversity of structural behavior in vertebrate conventional myosins complexed with actin. J. Mol. Biol. 369: 249-64.
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Málnási-Csizmadia, A., Tóth, J., Pearson, D. S., Hetényi, C., Nyitray, L., Geeves, M. A., Bagshaw, C. R., Kovács, M. (2007):
Selective perturbation of the myosin recovery stroke by point mutations at the base of the lever arm affects ATP hydrolysis and phosphate release. J. Biol. Chem. 282: 17658-64.
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Yang, Y., Gourinath, S., Kovács, M., Nyitray, L., Reutzel, R., Himmel, D. M., O'Neall-Hennessey, E., Reshetnikova, L., Szent-Györgyi, A. G., Brown, J. H., Cohen, C. (2007):
Rigor-like structures of muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor.
Structure 15: 553-64.
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Kovács, M., Thirumurugan, K., Knight, P. J., Sellers, J. R. (2007):
Load-dependent mechanism of non-muscle myosin 2. Proc. Natl. Acad. Sci. USA. 104: 9994-9.
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Tóth, J., Varga, B., Kovács, M., Málnási-Csizmadia, A., Vértessy, B. G. (2007):
Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme. J. Biol. Chem. 282: 33572-82.
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2006
Yang, Y.*, Kovács, M.*, Sakamoto, T.*, Zhang, F., Kiehart, D. P., Sellers, J. R. (2006):
Dimerized Drosophila myosin VIIa: a processive motor. Proc. Natl. Acad. Sci. USA 103: 5746-51.
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Forgács, E., Cartwright, S., Kovács, M., Sakamoto, T., Sellers, J. R., Corrie, J. E., Webb, M. R., White, H. D. (2006):
Kinetic mechanism of myosinV-S1 using a new fluorescent ATP analogue. Biochemistry 45:13035-45.
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Kintses, B., Simon, Z., Gyimesi, M., Tóth, J., Jelinek, B., Niedetzky, C., Kovács, M., Málnási-Csizmadia, A. (2006):
Enzyme kinetics above denaturation temperature: a temperature-jump/stopped-flow apparatus. Biophys J.91: 4605-10.
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2005
Kovács, M., Wang, F., Sellers, J. R. (2005):
Mechanism of action of myosin X, a membrane-associated molecular motor. J. Biol. Chem. 280: 15071-15083.
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Kim, K-Y.*, Kovács, M.*, Kawamoto, S., Sellers, J. R., Adelstein, R. S. (2005):
Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C. J. Biol. Chem. 280: 22769-75.
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Liu, X., Shu, S., Kovács, M., Korn, E. D. (2005):
Biological, biochemical and kinetic effects of mutations of the cardiomyopathy-loop of Dictyostelium myosin II: Importance of Ala400. J. Biol. Chem.280: 26974-83.
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Tóth, J., Kovács, M., Wang, F., Nyitray, L., Sellers, J. R. (2005):
Myosin V from Drosophila reveals diversity of motor mechanisms within the myosin V family. J. Biol. Chem. 280: 30594-603.
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Yang, Y.*, Kovács, M.*, Xu, E., Anderson, J. B., Sellers, J. R. (2005):
Myosin VIIB from Drosophila is a high duty ratio motor. J. Biol. Chem. 280: 32061-8.
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2004
Kovács, M., Tóth, J., Nyitray, L., Sellers, J. R. (2004):
Two-headed binding of the unphosphorylated non-muscle heavy meromyosin-ADP complex to actin. Biochemistry 43: 4219-26.
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Kovács, M., Tóth, J., Málnási-Csizmadia, A., Bagshaw, C. R., Nyitray, L. (2004):
Engineering lysine reactivity as a conformational sensor in the Dictyostelium myosin II motor domain. J. Muscle Res. Cell Motil. 25: 95-102.
PubMed Abstract
Kovács, M., Tóth, J., Hetényi, C., Málnási-Csizmadia, A., Sellers, J. R. (2004):
Mechanism of blebbistatin inhibition of myosin II. J. Biol. Chem. 279: 35557-63.
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2003
Wang, F.*, Kovács, M.*, Hu, A., Limouze, J., Harvey, E. V., Sellers, J. R. (2003):
Kinetic mechanism of non-muscle myosin IIB: functional adaptations for tension generation and maintenance. J. Biol. Chem. 278: 27439-48.
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Kovács, M.*, Wang, F.*, Hu, A., Zhang, Y., Sellers, J. R. (2003):
Functional divergence of human cytoplasmic myosin II: kinetic characterization of the non-muscle IIA isoform. J. Biol. Chem. 278: 38132-40.
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Conibear, P. B., Bagshaw, C. R., Fajer, P., Kovács, M., Málnási-Csizmadia, A. (2003):
Myosin cleft movement and its coupling to actomyosin dissociation. Nat. Struct. Biol. 10: 831-5.
PubMed Abstract
2002
Kovács, M., Málnási-Csizmadia, A., Woolley, J. R., Bagshaw, C. R. (2002):
Analysis of nucleotide binding to Dictyostelium myosin II motor domains containing a single tryptophan near the active site. J. Biol. Chem. 277: 28459-67.
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Wakelin, S., Woolley, R. J., Floyd, D. N., Bagshaw, C. R., Kovács, M., Málnási-Csizmadia, A. (2002):
Engineering Dictyostelium discoideum myosin II for the introduction of site-specific fluorescence probes. J. Muscle Res. Cell Motil. 23: 673-683.
PubMed Abstract
2001
Málnási-Csizmadia, A., Kovács, M., Woolley, J. R., Botchway, S. W., Bagshaw, C. R. (2001):
The dynamics of the relay loop tryptophan residue in the Dictyostelium myosin motor domain and the origin of spectroscopic signals. J. Biol. Chem. 276: 19483-90.
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Málnási-Csizmadia, A., Pearson, D. S., Kovács, M., Woolley, R. J., Geeves, M. A., Bagshaw, C. R. (2001):
Kinetic resolution of a conformational transition and the ATP hydrolysis step using relaxation methods with a Dictyostelium myosin II mutant containing a single tryptophan residue. Biochemistry 40: 12727-37.
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