Conference abstracts

2011

Gyimesi, M., Sarlós, K., Kovács, M. (2011): A minimal functional unit of the human BLM helicase. 55th Annual Meeting of the Biophysical Society, Baltimore, MD, USA

Nagy, N. T., Kovács, M. (2011): Allosteric tuning of myosin 5a motor activity. 55th Annual Meeting of the Biophysical Society, Baltimore, MD, USA

Sarlós, K., Gyimesi, M., Neuman, K.C., Kovács, M. (2011): Mechanochemistry of DNA helicases. HFSP Meeting, Montreal, Canada

Sarlós, K., Gyimesi, M., Neuman, K.C., Kovács, M. (2011): Temperature-dependent switch in the mechanochemical activity of RecQ helicases. Central European Meeting on Genome Stability and Dynamics, Bratislava, Slovakia

Gyimesi, M., Harami, G., Sarlós, K., Kovács, M. (2011): Basic homologous recombination activities can be performed by the minimal core of Bloom's syndrome helicase. Central European Meeting on Genome Stability and Dynamics, Bratislava, Slovakia

Kocsis, Z. S., Pintér, L, Haracska, L., Kovács, M. (2011): Non-canonical helicase in DNA repair. TÁMOP Meeting, Dobogókő, Hungary

Sarlós, K., Gyimesi, M., Kovács, M. (2011): Harnessing of chemical energy for mechanical work in DNA-restructuring enzymes. TÁMOP Meeting, Dobogókő, Hungary

Gyimesi, M., Sarlós, K., Harami, G., Kocsis, Z. S., Pires, R. H., Módos, K., Derényi, I., Kellermayer, M., Kovács, M. (2011): Stability and variability: genome-maintaining activities of DNA-restructuring motor enzymes. TÁMOP Meeting, Dobogókő, Hungary

Harami, G., Gyimesi, M., Sarlós, K., Kovács, M. (2011): Functional anatomy of the human Bloom’s syndrome helicase. FASEB Helicase Meeting, Steamboat Springs, CO, USA

Sarlós, K., Gyimesi, M., Pires, R. H., Módos, K., Kellermayer, M. S. Z., Kovács, M. (2011): Dynamic switch between assembly states of the human Bloom’s syndrome helicase during homologous recombination. FASEB Helicase Meeting, Steamboat Springs, CO, USA

Kocsis, Z. S., Pintér, L, Haracska, L., Kovács, M. (2011): ATPase properties of a non-canonical helicase. FASEB Helicase Meeting, Steamboat Springs, CO, USA

Kovács, M. (2011): Stability and variability: genome-maintaining activities of DNA-restructuring motor enzymes. 25th Anniversary of the Hungarian Scientific Research Fund (OTKA), Budapest, Hungary

Bibó, A., Károlyi, G., Kovács, M. (2011): Internal lever arm model for myosin II. Biochemical Society/Wellcome Trust Focused Meeting on Cellular cytoskeletal motor proteins, Hinxton, Cambridge, UK

Bibó, A., Károlyi, G., Kovács, M. (2011): Internal lever arm model for myosin II. Gordon Research Conference on Muscle & Molecular Motors, New London, NH, USA

Gyimesi, M., Harami, G., Sarlós, K., Roy, D., Kovács, M. (2011): Bloom’s syndrome helicase: functional anatomy of a DNA-restructuring motor protein. Annual Meeting of the Hungarian Biochemical Society, Pécs, Hungary

Harami, G., Gyimesi, M., Sarlós, K., Kovács, M. (2011): Enzymatic processes in DNA repair: Genome maintaining activities of RecQ helicases. 4th European Conference on Chemistry for Life Sciences, Budapest, Hungary

Nagy, N. T., Chakroborty, S., Sakamoto, T., Kovács, M. (2011): Allosteric tuning of myosin 5a motor activity. European Muscle Conference, Berlin, Germany

Málnási-Csizmadia, A., Kovács, M. (2011): Emerging complex pathways of the actomyosin powerstroke. European Muscle Conference, Berlin, Germany



2010

Bibó, A., Kovács, M., Károlyi, Gy. (2010): Internal lever arm model for myosin II. IUTAM Symposium on Dynamics Modeling and Interaction Control in Virtual and Real Environments, Budapest, Hungary

Gyimesi, M., Pires, R. H., Sarlós, K., Módos, K., Kellermayer, M. S., Kovács, M. (2010): The role of substrate induced oligomerization in the working mechanism of the human Bloom’s syndrome DNA helicase (BLM). Annual Meeting of the Hungarian Biochemical Society, Budapest, Hungary

Sarlós, K., Gyimesi, M., Kovács, M. (2010): Mechanism of DNA-dependent enzymatic activation of Escherichia coli RecQ helicase. 54th Annual Meeting of the Biophysical Society, San Francisco, CA, USA

Nagy, A., Takagi, Y., Homsher, E. E., Hong, D. K. T., Kovács, M., Sellers, J. R. (2010): Kinetic characterization of non-muscle myosin IIB single-headed heavy meromyosin on single molecule level with optical tweezers. 54th Annual Meeting of the Biophysical Society, San Francisco, CA, USA

Takács, B., O'Neall-Henessey, E., Hetényi, C., Kardos, J., Szent-Györgyi, A. G., Kovács, M. (2010): Myosin cleft closure determines the energetics of the actomyosin interaction. Conference on Muscle and Many other Motors, Alpbach, Austria

Gyimesi, M. Sarlós, K., Harami, G., Kocsis, Z., Kovács, M. (2010): Deciphering the mechanochemistry of RecQ-family DNA helicases. EMBO DNA Repair Meeting, Brno, Czech Republic



2009

Máté Gyimesi, Kata Sarlós, Mihály Kovács (2009): Working mechanism of the human Bloom’s syndrome helicase. 53rd Annual Meeting of the Biophysical Society, Boston, MA, USA

Nagy, A., Takagi, Y., Homsher, E., Kovács, M., Sellers, J. R. (2008): Single molecule kinetic measurements of non-muscle myosin IIB using optical tweezers. 53rd Annual Meeting of the Biophysical Society, Boston, MA, USA

Gyimesi, M., Sarlós, K., Kovács, M. (2009): Mechanism of translocation of the BLM helicase along DNA. Central-Eastern European INSTRUCT Meeting, Budapest

Gyimesi, M., Sarlós, K., Kovács, M. (2009): Mechanism of translocation of the BLM helicase along DNA. EMBO Young Investigator Meeting, Istanbul, Turkey

Gyimesi, M., Sarlós, K., Kovács, M. (2009): Processive translocation mechanism of the human Bloom’s syndrome helicase along single-stranded DNA. EMBO Meeting on Helicases and Nucleic Acid Machines, Les Diablerets, Switzerland

Sarlós, K., Gyimesi, M., Kovács, M. (2009): Mechanism of DNA-dependent enzymatic activation of Escherichia coli RecQ helicase. EMBO Meeting on Helicases and Nucleic Acid Machines, Les Diablerets, Switzerland

Gyimesi, M., Sarlós, K., Kovács, M. (2009): Processive translocation mechanism of the human Bloom’s syndrome helicase. Annual Meeting of the Hungarian Biochemical Society, Budapest, Hungary

Sarlós, K., Gyimesi, M., Kovács, M. (2009): Mechanism of DNA-dependent enzymatic activation of Escherichia coli RecQ helicase. Annual Meeting of the Hungarian Biochemical Society, Budapest, Hungary

Takács, B., Billington, N., Gyimesi, M., Kintses, B., Málnási-Csizmadia, A., Knight, P. J., Kovács, M. (2009): Blebbistatin stabilizes the start point of myosin’s force generation. Annual Meeting of the Hungarian Biochemical Society, Budapest, Hungary

Nagy, N., Sakamoto, T., Takács, B., Gyimesi, M., Sellers, J. R., Kovács, M. (2009): A class-specific structural adaptation of the switch-2 loop enables rapid processive translocation of myosin 5a. European Muscle Conference, Lille, France

Takacs, B., O'Neall-Henessey, E., Hetenyi, C., Kardos, J., Szent-Györgyi, A. G., Kovács, M. (2009): Myosin cleft closure determines the energetics of the actomyosin interaction. European Muscle Conference, Lille, France



2008

Nagy, N., Sellers, J. R., and Kovács, M. (2008):
Role of the switch-2 active site loop in the processive mechanism of myosin 5. 52nd Annual Meeting of the Biophysical Society, Long Beach, CA, USA

Takagi, Y., Yang, Y., Fujiwara, I., Jacobs, D., Cheney, R. E., Kovács, M., and Sellers, J. R. (2008):
Human myosin Vc is a low duty ratio, non-processive molecular motor. 52nd Annual Meeting of the Biophysical Society, Long Beach, CA, USA

Forgacs, E., Cartwright, S., Sakamoto, T., Belknap, B., Conyers, B., Tribby, M., Kovács, M., Tóth, J., Sellers, J. R., Webb, M. R., White, H. D. (2008): The effect of switch-1 mutation Ser217Ala on the kinetics of production dissociation and motor function of myosin V. 52nd Annual Meeting of the Biophysical Society, Long Beach, CA, USA

Nagy, N., Sarlós, K., Takács, B., Tóth, J., Yang, Y., Pearson, D. S., Hetényi, C., Nyitray, L., Málnási-Csizmadia, A., Geeves, M. A., Bagshaw, C. R., Sellers, J. R., Brown, J. H., Szent- Györgyi, A. G., Cohen, C., Kovács, M. (2008): Routes of allosteric communication between functional parts of the myosin motor. Scientific Meeting of International Research Scholars of the Howard Hughes Medical Institute, Lisbon, Portugal

Takács, B., O’Neall-Hennessey, E., Szent-Györgyi, A. G., Kovács, M. (2008): Diverse actin binding properties of myosin 2 isoforms. Annual Meeting of the Hungarian Biochemical Society, Szeged, Hungary

Sarlós, K., Málnási-Csizmadia, A., Kovács, M. (2008): Effect of mechanical load on the kinetics of an enzyme reaction. Annual Meeting of the Hungarian Biochemical Society, Szeged, Hungary

Gyimesi, M., Kovács, M. (2008): Mechanism of action of the human BLM helicase. Annual Meeting of the Hungarian Biochemical Society, Szeged, Hungary

Takács, B., Gyimesi, M., Kintses, B., Málnási-Csizmadia, A., Kovács, M. (2008): Utility of a myosin inhibitor in deciphering the structural mechanism of force generation. Chemistry towards Biology Conference, Dobogókő, Hungary

Takács, B., Gyimesi, M., Kintses, B., Málnási-Csizmadia, A., Kovács, M. (2008): Blebbistatin alters nucleotide-induced structural changes in myosin. European Muscle Conference, Oxford, U.K.

Nagy, A., Takagi, Y., Homsher, E., Kovács, M., Sellers, J. R. (2008): Single molecule kinetic measurements of non-muscle myosin IIB using optical tweezers. 48th Annual Meeting of the American Society for Cell Biology, San Francisco, CA



2007

Málnási-Csizmadia, A., Gyimesi, M., Kintses, B., Sellers, J. R., Kovács, M. (2007):
Blebbistatin alters nucleotide-induced structural changes in myosin. 51st Annual Meeting of the Biophysical Society, Baltimore, MD, USA.

Forgacs, E., Cartwright, S., Kovács, M., Tóth, J., Conyers, B., Tribby, M., Webb, M. R., Corrie, J. E. T., Sellers, J. R., White, H. D. (2007):
Mutational analysis of the myosinV active site. 51st Annual Meeting of the Biophysical Society, Baltimore, MD, USA.

Végner, L., Kintses, B., Kovács, M., Málnási-Csizmadia, A. (2007):
Heat induced protein unfolding initiated in low-stability “hot regions”. 51st Annual Meeting of the Biophysical Society, Baltimore, MD, USA.

Gyimesi, M., Kintses, B., Simon, Z., Tóth, J., Jelinek, B., Niedetzky, C., Kovács, M., Málnási-Csizmadia, A. (2007):
Enzyme kinetics above denaturation temperature: a temperature-jump/stopped-flow apparatus. FEBS Young Scientist Forum, Vienna, Austria.

Nagy, N., Kovács, M. (2007): Role of the switch-2 active site loop in the processive mechanism of myosin 5. Molecular Recognition Conference, Pécs, Hungary

Sarlós, K., Thirumurugan, K., Knight, P. J., Sellers, J. R., Kovács, M. (2007): Load-dependent mechanism of non-muscle myosin 2 enables highly efficient functioning. Molecular Recognition Conference, Pécs, Hungary

Sarlós, K., Málnási-Csizmadia, A., Kovács, M. (2007): Effect of mechanical load on the kinetics and thermodynamics of a motor enzyme reaction. Molecular Recognition Conference, Pécs, Hungary

Végner, L., Simon, Z., Kovács, M., Málnási-Csizmadia, A. (2007): Enzyme kinetics above denaturation temperature: a temperature-jump/stopped-flow apparatus. Molecular Recognition Conference, Pécs, Hungary

Sarlós, K., Thirumurugan, K., Knight, P. J., Sellers, J. R., Kovács, M. (2007): Load-dependent mechanism of non-muscle myosin 2 enables highly efficient functioning. Annual Meeting of the Hungarian Biochemical Society, Debrecen, Hungary

Takács, B., Gyimesi, M., Kintses, B., Málnási-Csizmadia, A., Kovács, M. (2007): Effect of blebbistatin on structural changes of myosin. Annual Meeting of the Hungarian Biochemical Society, Debrecen, Hungary

Nagy, N., Kovács, M. (2007): Role of the switch-2 active site loop in the processive mechanism of myosin 5. Annual Meeting of the Hungarian Biochemical Society, Debrecen, Hungary

Tóth, J., Varga, B., Kovács, M., Málnási-Csizmadia, A., Vértessy, B. (2007): Enzymatic mechanism of human dUTPase. Annual Meeting of the Hungarian Biochemical Society, Debrecen, Hungary

Takács, B., Gyimesi, M., Kintses, B., Málnási-Csizmadia, A., Kovács, M. (2007): Effect of blebbistatin on nucleotide-induced conformational changes of myosin. European Muscle Conference, Stockholm, Sweden



2006

Yang, Y., Kovács, M., Sakamoto, T., Kiehart, D. P., Sellers, J. R. (2006):
Drosophila myosin VIIa is a processive motor. 50th Annual Meeting of the Biophysical Society, Salt Lake City, UT, USA.

Iwamoto, H., Oiwa, K., Uyeda, T.Q.P., Kovács, M., Sellers, J. R., Wakayama, J., Tamura, T., Fujisawa, T., Yagi, N (2006):
Low-Resolution Structures of Complexes between Actin and Myosin-II Subfragments from Muscle and Non-muscle Sources as Studied by X-ray Diffraction. 50th Annual Meeting of the Biophysical Society, Salt Lake City, UT, USA.

Kovács, M., Thirumurugan, K., Knight, P. J., Sellers, J. R. (2006):
Load-dependent kinetics of non-muscle myosin II. Meeting of EMBO Young Investigators, Vienna, Austria.

Kovács, M., Thirumurugan, K., Knight, P. J., Sellers, J. R. (2006):
Load-dependent kinetics of non-muscle myosin II. EMBO/HHMI Central European Meeting, Dubrovnik, Croatia.

Kovács, M., Thirumurugan, K., Knight, P. J., Sellers, J. R. (2006):
Load-dependent kinetics of non-muscle myosin II. Scientific Meeting of International Research Scholars of the Howard Hughes Medical Institute, Ashburn, VA, USA.

Németh, A., Süveges, D., Kovács, M., Nyitray, L. (2006):
Kinetic investigation of myosin regulation. 11th Workshop of the Hungarian Biochemical Society, Pécs, Hungary



2005

Kovács, M., Wang, F., Tóth, J., Hu, A., Limouze, J., Sellers, J. R. (2005):
Functional diversity of non-muscle myosin II isoforms. 49th Annual Meeting of the Biophysical Society, Long Beach, CA, USA.

Kovács, M., Wang, F., Sellers, J. R. (2005):
Mechanism of action of the membrane motor myosin X. 49th Annual Meeting of the Biophysical Society, Long Beach, CA, USA.

Kovács, M., Wang, F., Sellers, J. R. (2005):
Load-dependent kinetics of non-muscle myosin II. 3rd Annual Fellows Retreat of the National Heart, Lung and Blood Institute, St. Michaels, MD, USA.

Tóth, J., Kovács, M., Wang, F., Sellers, J. R. (2005):
Drosophila myosin V: solution kinetics and motile properties. 3rd Annual Fellows Retreat of the National Heart, Lung and Blood Institute, St. Michaels, MD, USA.

Tóth, J., Kovács, M., Wang, F., Nyitray, L., Sellers, J. R. (2005):
Drosophila myosin V: solution kinetics and motile properties. 30th FEBS Congress - 9th IUBMB Conference, Budapest, Hungary

Kovács, M., Wang, F., Thirumurugan, K., Knight, P. J., Sellers, J. R. (2005):
Load-dependent kinetics of non-muscle myosin II. Gordon Research Conference on Muscle and Contractile Proteins, New London, NH, USA.

Kovács, M., Sellers, J. R. (2005):
All myosins are unconventional. International Conference on Motor Proteins and the Cytoskeleton, Hamburg, Germany.



2004

Kovács, M., Tóth, J., Sellers, J. R. (2004):
Blebbistatin alters actin and nucleotide interaction of myosin II in a unique manner. 48th Annual Meeting of the Biophysical Society, Baltimore, MD, USA.

Kovács, M., Tóth, J., Hetényi, C., Málnási-Csizmadia, A., Sellers, J. R. (2004):
Blebbistatin alters actin and nucleotide interaction of myosin II in a unique manner. 11th Workshop on Molecular Motors, Alpbach, Austria.

Málnási-Csizmadia, A., Kovács, M. (2004):
Factors determining the rates of enzyme reactions. 9th Workshop of the Hungarian Biochemical Society, Sopron, Hungary

Kim, K. Y., Preston, Y. A., Kovács, M., Harvey, E. V., Sellers, J. R., Adelstein, R. S (2004):
Characterization of the enzymatic function of nonmuscle heavy meromyosin II-B and II-C. 2nd Annual Fellows Retreat of the National Heart, Lung and Blood Institute, Warrenton, VA, USA.

Kovács, M., Wang, F., Sellers, J. R. (2004):
Unique mechanism of action of myosin-X, a membrane motor. 2nd Annual Fellows Retreat of the National Heart, Lung and Blood Institute, Warrenton, VA, USA.

Kovács, M., Wang, F., Sellers, J. R. (2004):
Unique mechanism of action of myosin-X, a membrane motor. 33rd European Muscle Conference, Isola d’Elba, Italy.

Kovács, M., Wang, F., Sellers, J. R. (2004):
Unique mechanism of action of myosin-X, a membrane motor. NIH Research Festival, Bethesda, MD, USA.

Kovács, M., Wang, F., Sellers, J. R. (2004):
Unique mechanism of action of myosin-X, a membrane motor. 44th Annual Meeting of the American Society for Cell Biology, Washington, DC, USA.

Kim, K. Y., Kovács, M., Preston, Y. A., Harvey, E. V., Kawamoto, S., Sellers, J. R., Adelstein, R. S. (2004):
Mutations in nonmuscle myosin heavy chain II-B and II-C associated with diseases result in the impairment of enzymatic activity. 44th Annual Meeting of the American Society for Cell Biology, Washington, DC, USA.



2003

Málnási-Csizmadia, A., Kovács, M., Fajer, P. G., Conibear, P. B., Woolley, R. J., Bagshaw, C. R. (2003):
Probes of the myosin cleft that sense actin binding. 47th Annual Meeting of the Biophysical Society, San Antonio, TX, USA.

Kovács, M., Wang, F., Hu, A., Limouze, J., Sellers, J. R. (2003):
Kinetic mechanism of human non-muscle myosin II isoforms. 47th Annual Meeting of the Biophysical Society, San Antonio, TX, USA.

Kovács, M., Wang, F., Hu, A., Limouze, J., Sellers, J. R. (2003):
Functional divergence of human non-muscle myosin II isoforms. 1st Annual Fellows Retreat of the National Heart, Lung and Blood Institute, Washington, DC, USA.

Rodgers, P., Okoh, J., Sellers, J. R., Kovács, M. (2003):
Engineering of a Single-Headed Myosin II-C Construct in pFastBac Vector for Kinetic Characterization. 3rd Annual Biomedical Research Conference for Minority Students, San Diego, CA, USA.

Kovács, M., Tóth, J., Sellers, J. R. (2003):
Two-headed actin binding of the unphosphorylated non-muscle myosin IIA-ADP complex. 43rd Annual Meeting of the American Society for Cell Biology, San Francisco, CA, USA.



2002

Málnási-Csizmadia, A., Woolley, R. J., Tóth, J., Nyitray, L., Bagshaw, C. R., Kovács, M. (2002):
Fine tuning of ATP hydrolysis rate by subdomain interactions in myosin. 46th Annual Meeting of the Biophysical Society, San Francisco, CA, USA.

Kovács, M., Málnási-Csizmadia, A., Woolley, R. J., Bagshaw, C. R. (2002):
Precise resolution of myosin nucleotide binding process. 46th Annual Meeting of the Biophysical Society, San Francisco, CA, USA.



2001

Kovács, M., Málnási-Csizmadia, A., Woolley, R. J., Bagshaw, C. R. (2001):
Identification of tryptophan residues sensitive to nucleotide binding to Dictyostelium myosin II motor domain. 10th Workshop on Molecular Motors, Alpbach, Austria.

Málnási-Csizmadia, A., Woolley, R. J., Kovács, M., Bagshaw, C. R. (2001):
Resolution of conformational states of Dictyostelium myosin II motor domain using tryptophan (W501) mutants. 10th Workshop on Molecular Motors, Alpbach, Austria.

Kovács, M., Málnási-Csizmadia, A., Woolley, R. J., Bagshaw, C. R. (2001):
Establishing the correspondence between kinetic and conformational states of the myosin ATPase using Trp-mutant Dictyostelium myosin fragments. 6th Workshop of the Hungarian Biochemical Society, Sárospatak, Hungary

Kovács, M., Málnási-Csizmadia, A., Woolley, R. J., Bagshaw, C. R. (2001):
Kinetic characterisation of nucleotide binding to myosin mutants containing a single tryptophan near the active site. 30th European Muscle Conference, Pavia, Italy.

Málnási-Csizmadia, A., Pearson, D. S., Kovács, M., Woolley, R. J., Geeves, M. A., Bagshaw, C. R. (2001):
Direct evidence that the open-closed transition and ATP hydrolysis are separate steps in the myosin mechanism. 30th European Muscle Conference, Pavia, Italy.
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